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Dandy-Walker-like malformation (DWLM), a form of cerebellar hypoplasia (CH), is a disorder caused by abnormal brain development, which in turn causes a lack of muscle coordination.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
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General information
Dandy-Walker-like malformation (DWLM), a form of cerebellar hypoplasia (CH), is a disorder caused by abnormal brain development, which in turn causes a lack of muscle coordination. DWLM in the Eurasier is caused by a recessive mutation to the gene VLDLR.
Clinical features
Affected dogs begin to present symptoms when they start to walk. These symptoms include rolling and/or leaning, tremors, hypermetric gait (movement of the legs beyond the intended goal), loss of menace response and other difficulties potentially due to processing information of the senses.
Additional information
References
Pubmed ID: 25668033
Omia ID: 1947