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Upper Airway Syndrome (NTUAS) is a breathing disorder found in dogs.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 13 |
| Mutation | c.2786G>A |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Unknown |
| Also known as | UAS |
General information
Upper Airway Syndrome (NTUAS) is a breathing disorder found in dogs. The disorder is linked to a mutation to the gene ADAMTS3. The mutation has been found in, amongst others, Norwich Terrier, (French) Bulldog and Staffordshire Bull Terrier.
NTUAS has an symptoms overlap with Brachycephalic Obstructive Airway Syndrome (BOAS), a disorder that causes breathing difficulties in brachycephalic dogs.
The main issues in affected dogs include a slightly elongated soft palate, extra tissue in the throat, and structural changes in the larynx. These abnormalities, caused by the ADAMTS3 mutation, can lead to breathing difficulties of varying severity. Further research is needed to fully understand the range of symptoms.
Clinical features
Affected dogs may experience breathing difficulties, often accompanied by stridor (wheezing or snorting sounds). Other possible symptoms include enlarged or swollen tonsils and partial laryngeal collapse. Diagnosis can be challenging without a laryngoscopic examination.
Additional information
References
Pubmed ID: 31095560
Year published: 2019
Omia ID: 1893
Omia variant ID: