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Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery.
This specific variant of the disease is found in the Labrador Retriever. Other variants are found in multiple breeds, such as the German Shepherd, Rhodesian Ridgeback and Irish Setter.
Clinical features
Common clinical signs in dogs include bleeding from the mouth, subcutaneous and intramuscular haematomas and lameness.
Additional information
References
Pubmed ID: 37438956
Omia ID: 437