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Coat colour in cats is controlled by a wide range of different genes working together.
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Specifications
Breeds | |
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Gene | |
Organ | |
specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
Mode of Inheritance | |
Chromosome | |
Also known as | |
Year Published |
General information
Coat colour in cats is controlled by a wide range of different genes working together. These genes are often referred to as “loci”. The C-Locus, a.k.a. Colour Locus, corresponds to the gene for tyrosinase (TYR). Recessive mutations to TYR can cause various degrees of Type 1 Oculocutaneous Albinism (OCA1), a failure to produce pigment, which leads to a silvery-white coat and light-coloured eyes. This can range between the distinctive point colouration of the Siamese cat, to full albinism.
The mutation analysed in this test, designated as “cs”, is responsible for Siamese-type point colouration. It is recessive to the normal genotype (“C”), but dominant over most other C-Locus mutations. A cat that carries one cs and one cb allele will display a mink coat instead.
Clinical features
Affected cats have a point colouration, with a white body and darkened extremities.
In Bengal cats, this mutation results in the Snow coat type.
Additional information
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a cat's coat colour genetics.
References
Pubmed ID: 15771720
Omia ID: 202