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H709

Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease. This variant of the disease, CLAD Type I, is caused by a recessive mutation in the ITGB2 gene, which encodes the leukocyte integrin beta-2 subunit (CD18). The disease is found in the Irish Setter

Clinical features

Clinical features include severe infections of omphalophlebitis, skin infections, osteomyelitis, gingivitis, fever, anorexia, lameness, impaired wound healing, severe skin infections, salivation, thickened mandible, enlarged metaphyses of the distal radius, ulna, tibia, fibula, lameness, enlarged lymph nodes, and low body weight. Untreated dogs often die by 6 months of age.

Additional information

References

Pubmed ID: 10512685

Omia ID: 595

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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