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Familial Shar-Pei Fever, also called Shar-Pei Autoinflammatory Disease (SPAID) is an inherited autoimmune condition characterised by recurrent fever attacks and arthritis (swollen and painful heels).
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Familial Shar-Pei Fever, also called Shar-Pei Autoinflammatory Disease (SPAID) is an inherited autoimmune condition characterised by recurrent fever attacks and arthritis (swollen and painful heels). Therefore it is also called “Swollen Hock Syndrome”. A causal mutation responsible for the disease was identified in the MTBP gene.
Clinical features
Clinical signs of SPAID are fever, pain in the hind legs, excessive drinking and excessive urination. Shar-Pei/Shar Pei/Sharpei Fever can be treated by a veterinarian through painkillers and medication to support kidney functions and reduce fever.
Additional information
The predisposition of an autosomal dominant disease can be inhered by one parent. However, this disease is reported as incomplete dominant in which researchers show that the phenotype cannot be explained by the dominant mode of inheritance only. More research needs to be performed in order to fully explain this phenotype.
References
Pubmed ID: 28472921
Omia ID: 1561