€57,48 €47,50 excl. VAT
Congenital Hypothyroidism with Goiter (CHG), sometimes just called Hypothyroidism, is a deficiency of the thyroid gland, which can cause growth retardation and lethargy.
10 working days
From €5,95 shipping and administration per order (incl. VAT)
Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Congenital Hypothyroidism with Goiter (CHG), sometimes just called Hypothyroidism, is a deficiency of the thyroid gland, which can cause growth retardation and lethargy. This variant of the disease, found in the Spanish Water Dog, is caused by a recessive mutation to the TPO gene. Similar variants occur in the Rat Terrier and Toy Fox Terrier, the Tenterfield Terrier, and the French Bulldog.
Clinical features
Affected puppies develop more slowly than their littermates, moving less, nursing poorly and opening their eyes later. They also develop goiters (progressively-enlarging swellings on the underside of the neck). Skeletal abnormalities and deafness can result. CHG can be partially treated through oral thyroid hormone replacement, which can increase growth rate, activity and alertness.
Additional information
References
Pubmed ID: 23223904
Omia ID: 536