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Coat colour in dogs is controlled by a wide range of different genes working together.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Extension, or E-Locus, corresponds to the gene ‘melanocortin 1 receptor’ (MC1R), which is involved in the regulation of pigment production.
This E-locus variant, designated as Grizzle or E ^G, is a dominant mutation unique to the Saluki and Afghan Hound. It results in a coat colouration pattern known as ‘grizzle’ in the Saluki, and as ‘domino’ in the Afghan Hound.
Clinical features
Affected dogs (E^G/E^G, E^G/E or E^G/e) develop darkened fur on the top and sides of the body and the outside of the limbs. The contrast between the darker hair on the head with the lighter hair on the face is often called a ‘widow’s peak’.
Additional information
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.
References
Pubmed ID: 20525767
Omia ID: 1495